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| Product Name | Recombinant Rat Fractalkine protein (Cx3cl1) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 26.69kDa. Extracellular Domain: 24-247aa. C-terminal 6xHis-tagged. Homo sapiens (Human). The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type (immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | T-Lymphocyte Activation Antigen CD86; Activation B7-2 Antigen; B70; BU63; CTLA-4 Counter-Receptor B7.2; FUN-1; CD86; CD28LG2 |
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| Gene, Accession, CAS # | CD86, UniProt: P42081 |
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| Catalog # | RPC26962 |
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| Order / More Info | Recombinant Rat Fractalkine protein (Cx3cl1) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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