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| Product Name | Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 (mcr1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 56.7kDa. Partial: 178-541aa. N-terminal 6xHis-SUMO-tagged. Escherichia coli. Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).1 Publication Confers resistance to polymyxin-type antibiotics; expression of the Mcr-2 prin in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Polymyxin resistance protein MCR-1 |
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| Gene, Accession, CAS # | mcr1, UniProt: A0A0R6L508 |
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| Catalog # | RPC23207 |
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| Order / More Info | Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 (mcr1), partial from BIOMATIK |
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| Product Specific References | n/a |
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