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| Product Name | Arginase I (ARG1) Inhibitor Screening Kit (Colorimetric) |
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| Description | Arginase (EC 3.5.3.1) is a manganese-containing enzyme which catalyzes the conversion of arginine into urea and ornithine, which is the final reaction in the urea cycle. Arginase I (ARG1) is the liver isoform of arginase. Recent studies showed that ARG1 expression by mature myeloid cells in tumor environment as demonstrated in a 3LL murine lung carcinoma model causes L-Arginine depletion by tumor-associated myeloid cells (TAMC). L-arginine depletion suppresses immune-response against tumor cells due to inhibition to T-cell proliferation. In addition, the depletion of arginine increases the reactive nitrogen species (NOS) and reactive oxygen species (ROS), which, in consequence, induce T-cell apoptosis and supports antigenic cell proliferati |
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| Size | 100 assays |
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| Concentration | n/a |
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| Applications | • Screening for inhibitors of human arginase I (ARG1) |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | K567-100 |
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| Order / More Info | Arginase I (ARG1) Inhibitor Screening Kit (Colorimetric) from BIOVISION, INC. |
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| Product Specific References | n/a |
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