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| Product Name | Recombinant Human Serine/arginine-rich splicing factor 1 (SRSF1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 43.6kDa. Full Length of Mature Protein: 2-248aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Alternative-splicing factor 1; ASF-1Splicing factor, arginine/serine-rich 1pre-mRNA-splicing factor SF2, P33 subunit |
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| Gene, Accession, CAS # | SRSF1, UniProt: Q07955 |
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| Catalog # | RPC21996 |
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| Order / More Info | Recombinant Human Serine/arginine-rich splicing factor 1 (SRSF1) from BIOMATIK |
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| Product Specific References | n/a |
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