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| Product Name | Recombinant Candida albicans pH-regulated antigen PRA1 (PRA1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 33.4kDa. Full Length of Mature Protein: 16-299aa. N-terminal 6xHis-tagged. Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 58 kDa fibrinogen-binding mannoprotein; FBP1 |
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| Gene, Accession, CAS # | PRA1, UniProt: P87020 |
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| Catalog # | RPC25610 |
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| Order / More Info | Recombinant Candida albicans pH-regulated antigen PRA1 (PRA1) from BIOMATIK |
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| Product Specific References | n/a |
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