| 产品详情 |
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| Antigenic Specificity | Activated c1s |
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| Clone | M241 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunoassay (IA),Western Blotting (WB),Immunoprecipitation (IP),Flow Cytometry (FACS),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Inhibition Assay (InhA) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s. |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN2191987 |
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| Price | |
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| Order / More Info | Activated c1s Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2522968 |
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| 产品资料 |
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