| 产品详情 |
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| Product Name | Recombinant Human Homer protein homolog 1 (HOMER1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 44.3kDa. Full Length: 1-354aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Postsynaptic density scaffolding protein. Binds and cross-links Cytoplasmic domain regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | HOMER1, UniProt: Q86YM7 |
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| Catalog # | RPC24020 |
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| Order / More Info | Recombinant Human Homer protein homolog 1 (HOMER1) from BIOMATIK |
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| Product Specific References | n/a |
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