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| Product Name | Recombinant Human immunodeficiency virus type 1 group M subtype B Virion infectivity factor (vif) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 38.5kDa. Full Length: 1-192aa. N-terminal 6xHis-sumostar-tagged. Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1). Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | SOR protein |
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| Gene, Accession, CAS # | vif, UniProt: P69721 |
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| Catalog # | RPC25044 |
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| Order / More Info | Recombinant Human immunodeficiency virus type 1 group M subtype B Virion infectivity factor (vif) from BIOMATIK |
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| Product Specific References | n/a |
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