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| Product Name | Recombinant Human immunodeficiency virus type 1 group M subtype K Protein Vpr (vpr) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 18.8kDa. Full Length: 1-96aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1). During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.During virus entry, plays a role in the transport of the viral pre-integration complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine-repeat regions. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | R ORF protein (Viral protein R) |
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| Gene, Accession, CAS # | vpr, UniProt: P0C1P2 |
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| Catalog # | RPC25803 |
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| Price | |
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| Order / More Info | Recombinant Human immunodeficiency virus type 1 group M subtype K Protein Vpr (vpr) from BIOMATIK |
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| Product Specific References | n/a |
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