| 产品详情 |
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| Product Name | LX-2343 |
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| Description | LX-2343 is a neuroprotective agent for the treatment of Alzheimer's disease. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion. LX2-343 dose-dependently decreases Aβ accumulation in HEK293-APPsw and CHO-APP cells,and promotes Aβ clearance in SH-SY5Y cells and primary astrocytes. The anti-amyloid effects of LX2343 are attributed to suppressing JNK-mediated APPThr668 phosphorylation, thus inhibiting APP cleavage on one hand, and inhibiting BACE1 enzymatic activity with an IC50 value of 11.43±0.36 µmol/L, on the other hand. MW: 474.91. Purity ≥98% by HPLC |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide |
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| Gene, Accession, CAS # | CAS: 333745-53-2 |
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| Catalog # | B2120-5 |
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| Order / More Info | LX-2343 from BIOVISION, INC. |
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| Product Specific References | n/a |
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