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| Product Name | Recombinant Shigella flexneri serotype X E3 ubiquitin-protein ligase ipaH9.8 (ipaH9.8) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 66kDa. Full Length: 1-545aa. N-terminal 6xHis-tagged. Shigella flexneri serotype X (strain 2002017). Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. Interacts with IKBKG (NO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG. Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection. Uses UBE2D2 (UBCH5B) as an E2 ubiquitin-conjugating enzyme. Mediates polyubiquitination of host U2AF1, leading to its proteasomal degradation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Invasion plasmid antigen ipaH9.8 |
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| Gene, Accession, CAS # | ipaH9.8, UniProt: D2AJU0 |
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| Catalog # | RPC22873 |
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| Order / More Info | Recombinant Shigella flexneri serotype X E3 ubiquitin-protein ligase ipaH9.8 (ipaH9.8) from BIOMATIK |
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| Product Specific References | n/a |
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