| 产品详情 |
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| Product Name | (±)11(12)-EET |
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| Description | Purity >95%. (±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET , to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid, (±)11,12-EpETrE |
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| Gene, Accession, CAS # | CAS: 123931-40-8 |
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| Catalog # | LS-H5478 |
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| Price | |
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| Order / More Info | (±)11(12)-EET from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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