| 产品详情 |
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| Product Name | PF-05274857 (hydrochloride) |
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| Description | An antagonist which binds Smo (Ki = 4.6 nM), blocking Gli1 transcription in cells stimulated with Shh (IC50 = 2.7 nM); orally available, metabolically stable, and able to penetrate the blood-brain barrier |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1373615-35-0 receptors antagonists cancers stems cells research smoothened Smo blocks blocking Gli1 Gli-1 Gli 1 Shh sonic hedgehogs plasma skin tumors metabolically stable blood brains barriers blood-brain inhibits inhibitions inhibitors PF05274857 Hcl PF-05274857 PF-5274857 PF5274857 PFs 05274857 5274857 signals signaling binds bindings ligands patched 1 transcriptions cells stimulations stimulates oral orally |
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| Gene, Accession, CAS # | CAS: 1613439-62-5 |
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| Catalog # | 15022-10 |
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| Order / More Info | PF-05274857 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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