| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse Nucleophosmin (Npm1) |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 48.6kDa. Full Length: 1-292aa. N-terminal 6xHis-SUMO-tagged. Mus musculus (Mouse). Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin |
|---|
| Gene, Accession, CAS # | Npm1, UniProt: Q61937 |
|---|
| Catalog # | RPC20406 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse Nucleophosmin (Npm1) from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|