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| Product Name | Soluble IL-6 Receptor alpha (sIL-6R Alpha) (Isoform 1), (AA 20-358) (Active) protein (His tag) |
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| Description | Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2Molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both na ve and memory CD4 T-cells and strongly augments IL-6 ligand's induction of Th-17 cells.Recombinant human Soluble IL-6 Receptor Alpha (rhsIL-6R alpha) with an N-terminal His tag produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 350 amino acids. A fully biologically active molecule, rhsIL-6R alpha has a molecular mass of 50kDa analyzed by reducing SDS-PAGE. Synonyms: gp80 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN2018356 |
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| Order / More Info | Soluble IL-6 Receptor alpha (sIL-6R Alpha) (Isoform 1), (AA 20-358) (Active) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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