| 产品详情 |
| Edit |   |
|---|
| Product Name | Triapine |
|---|
| Description | 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 µM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. In addition, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis. MW: 195.24. Purity ≥98% by HPLC |
|---|
| Size | 50 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone; 3-AP; NSC 663249 |
|---|
| Gene, Accession, CAS # | CAS: 143621-35-6 |
|---|
| Catalog # | B1174-50 |
|---|
| Price | |
|---|
| Order / More Info | Triapine from BIOVISION, INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|