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| Product Name | Triapine |
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| Description | 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 µM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. In addition, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis. MW: 195.24. Purity ≥98% by HPLC |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone; 3-AP; NSC 663249 |
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| Gene, Accession, CAS # | CAS: 143621-35-6 |
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| Catalog # | B1174-10 |
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| Order / More Info | Triapine from BIOVISION, INC. |
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| Product Specific References | n/a |
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