| 产品详情 |
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| Product Name | AT-13148 |
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| Description | MW: 313.78. Purity ≥98% by HPLC. AT13148 is a potent; ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity. AT13148 blocks AKT; p70S6K; PKA; ROCK; and SGK substrate phosphorylation inducing concentration dependent apoptosis in cancer cells. It also shows anti-tumor efficacy in HER2-positive; PIK3CA-mutant BT474 breast; PTEN-deficient PC3 human prostate cancer and PTEN deficient MES-SA uterine tumor in xenografts. Gene expression studies shows that AT13148 has a predomin |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [(S)-1- (4- (1H-pyrazol-4-yl) phenyl)-2-amino-1- (4-chlorophenyl) ethanol] |
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| Gene, Accession, CAS # | CAS: 1056901-62-2 |
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| Catalog # | MBS846287 |
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| Order / More Info | AT-13148 from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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