产品名称

ONX 0914 - PR 957

产品货号

Axon 2199 CAS [960374-59-8] MF C31H40N4O7MW 580.67 Purity: 98% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Selective inhibitor of LMP7, the chymotrypsin-like subunit of the immunoproteasome. ONX 0914 blocks the production of cytokines IL-23, TNF-α, and IL-6 in a NF-κB independent manner, and attenuates progression of experimental arthritis in mouse models.ONX 0914 induces an anti-inflammatory response at doses less than one tenth of the maximum tolerated dose, in contrast to nonselective inhibitors, such as bortezomib (Axon 1810) and carfilzomib. References Certificates Categories Extra info T. Muchamuel et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat. Med. 2009, 15, 781-788. S.E. Verbrugge et al. Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (...). J. Pharmacol. Exp. Ther. 2012, 341, 174-182. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology Pain & Inflammation Immunomodulator Proteasome 26S Ubiquitin EC 3.4 Selective inhibitor of LMP7 subunit of the immunoproteasome. Chemical name (S)-3-(4-methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide Parent CAS No. [960374-59-8] Order Size Unit Price Stock 2 mg €95.00 In Stock

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axonmedchem

产品概述

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ONX 0914 - PR 957

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2199

CAS [960374-59-8]

MF C31H40N4O7
MW 580.67

Purity: 98%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

ONX 0914

Description

Selective inhibitor of LMP7, the chymotrypsin-like subunit of the immunoproteasome. ONX 0914 blocks the production of cytokines IL-23, TNF-α, and IL-6 in a NF-κB independent manner, and attenuates progression of experimental arthritis in mouse models.
ONX 0914 induces an anti-inflammatory response at doses less than one tenth of the maximum tolerated dose, in contrast to nonselective inhibitors, such as bortezomib (Axon 1810) and carfilzomib.

T. Muchamuel et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat. Med. 2009, 15, 781-788.

S.E. Verbrugge et al. Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (...). J. Pharmacol. Exp. Ther. 2012, 341, 174-182.

Cell Signaling & Oncology Immunology Pain & Inflammation Immunomodulator Proteasome 26S Ubiquitin EC 3.4

Selective inhibitor of LMP7 subunit of the immunoproteasome.

Chemical name

(S)-3-(4-methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide

Parent CAS No.

[960374-59-8]

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