产品名称

Pirfenidone - AMR-69

产品货号

Axon 2647 CAS [53179-13-8] MF C12H11NOMW 185.22 Purity: 100% Soluble in DMSO Description Orally available agent with therapeutic potential for idiopathic pulmonary fibrosis (IPF; IC50 value 14.44 mM for inhibition of cell proliferation against MRC-5 cells) that has combined anti-inflammatory, antioxidant and antifibrotic effects in experimental models of pulmonary fibrosis. Mechanistically, Pirfenidone inhibits not only TGF-β-induced Smad3, p38 and Akt phosphorylation in human lung fibroblasts (HLFs), but also significantly increased RGS2 mRNA and protein expression in fibroblasts. KEYWORDS: Pirfenidone | supplier | anti-inflammatory | anti-fibrosis agent | AMR-69 | AMR69 | CAS [53179-13-8] | Immunology | idiopathic | pulmonary fibrosis | IPF | antioxidant | antifibrotic | TGF-β | Smad3 | p38 | Akt | RGS2

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Pirfenidone - AMR-69

Based on 967 publications in PubMed 8 10 967

Axon 2647

CAS [53179-13-8]

MF C12H11NO
MW 185.22

Purity: 100%
Soluble in DMSO

Pirfenidone

Description

Orally available agent with therapeutic potential for idiopathic pulmonary fibrosis (IPF; IC50 value 14.44 mM for inhibition of cell proliferation against MRC-5 cells) that has combined anti-inflammatory, antioxidant and antifibrotic effects in experimental models of pulmonary fibrosis. Mechanistically, Pirfenidone inhibits not only TGF-β-induced Smad3, p38 and Akt phosphorylation in human lung fibroblasts (HLFs), but also significantly increased RGS2 mRNA and protein expression in fibroblasts.