产品名称 Eact
产品货号 Axon 2576 CAS [461000-66-8] MF C22H24N2O5SMW 428.50 Purity: 100% Soluble in DMSO Description Strong activator of TMEM16A (ANO1; calcium activated chloride channel;CaCC) without elevating cytoplasmic Ca2+, producing outwardly rectifying currents (EC50 value 3 µM). Eact increases secretion by submucosal glands, as well as by airway surface cells exposed to a proinflammatory milieu; may be useful for treatment of cystic fibrosis (CF), dry mouth, and dry eye syndromes, and motility disorders of the gastrointestinal tract. KEYWORDS: Eact | supplier | TMEM16A activator | CAS [461000-66-8] | Chloride | ANO1 | calcium activated chloride channel | CaCC | Ion Channel | rectifying current | secretion | cystic fibrosis | CF | dry | motility disorder | gastrointestinal tract
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产品品牌 axonmedchem
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Eact

Based on 5 publications in PubMed 9 10 5

Axon 2576

CAS [461000-66-8]

MF C22H24N2O5S
MW 428.50

  • Purity: 100%
  • Soluble in DMSO

Eact

Description

Strong activator of TMEM16A (ANO1; calcium activated chloride channel;CaCC) without elevating cytoplasmic Ca2+, producing outwardly rectifying currents (EC50 value 3 µM). Eact increases secretion by submucosal glands, as well as by airway surface cells exposed to a proinflammatory milieu; may be useful for treatment of cystic fibrosis (CF), dry mouth, and dry eye syndromes, and motility disorders of the gastrointestinal tract.

KEYWORDS: Eact | supplier | TMEM16A activator | CAS [461000-66-8] | Chloride | ANO1 | calcium activated chloride channel | CaCC | Ion Channel | rectifying current | secretion | cystic fibrosis | CF | dry | motility disorder | gastrointestinal tract

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