| 产品名称 | AT 13148 dihydrochloride |
| 产品货号 | Axon 2166 CAS [1056901-62-2] MF C17H16ClN3O.2HClMW 386.70 Purity: 98% Soluble in DMSO Description An oral, ATP-competitive inhibitor of multi-AGC kinases with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 caused substantial blockade of AKT, p70S6K (S6K1), PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in cancer cells, with IC50 values of 38, 402, 50, 8, 3, 6, 4, 63 nM for AKT1, AKT2, AKT3, p70S6K, PKA, ROCK1, ROCK2, and SGK3 respectively. References Certificates Categories Extra info TA Yap et al. AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Clin. Cancer Res. 2012. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology ROCK Akt PKA PI3K-Akt-mTOR EC 2.7.11.1 SGK ATP-competitive inhibitor of multi-AGC kinases Chemical name (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol dihydrochloride Parent CAS No. [1056901-62-2] Order Size Unit Price Stock 2 mg €85.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
AT 13148 dihydrochlorideAxon 2166 CAS [1056901-62-2] MF C17H16ClN3O.2HCl
Description
An oral, ATP-competitive inhibitor of multi-AGC kinases with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 caused substantial blockade of AKT, p70S6K (S6K1), PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in cancer cells, with IC50 values of 38, 402, 50, 8, 3, 6, 4, 63 nM for AKT1, AKT2, AKT3, p70S6K, PKA, ROCK1, ROCK2, and SGK3 respectively.
ATP-competitive inhibitor of multi-AGC kinases
Chemical name(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol dihydrochloride Parent CAS No.[1056901-62-2] |
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