产品名称

Y 27632 dihydrochloride

产品货号

Axon 1683 CAS [129830-38-2] MF C14H21N3O.2HClMW 320.26 Purity: 100% Optical purity: >98% ee Soluble in water and DMSO Description Selective inhibitor of Rho-Kinase (ROCK), with IC50 values of 140-220 nM for ROCK1 and ROCK2. Y-27632 was found to increase human embryonic stem cell (hESC) survival *Promotion

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Y 27632 dihydrochloride

Based on 2872 publications in PubMed 9 10 2872

Axon 1683

CAS [129830-38-2]

MF C14H21N3O.2HCl
MW 320.26

Purity: 100%
Optical purity: >98% ee
Soluble in water and DMSO

Y 27632 dihydrochloride

Description

Selective inhibitor of Rho-Kinase (ROCK), with IC50 values of 140-220 nM for ROCK1 and ROCK2. Y-27632 was found to increase human embryonic stem cell (hESC) survival

*Promotion: Y 27632 is also part of Inhibitor Set(s):

KEYWORDS: Y 27632 dihydrochloride | supplier | ROCK inhibitor | Y-27632 | Y27632 HCl | CAS [129830-38-2] | [146986-50-7] | Phosphorylation | ROCK | Inhibitor | Rho-associated protein kinase | AGC | ROCK1 | ROCK2 | human | embryonic | stem cell | hESC | survival

T Ishizaki et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000, 57, 976-983.

K Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol. 2007, 25, 681-686.

C Doe et al. Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities. J. Pharmacol. Exp. Ther. 2007, 320, 89-98.

D Schaafsma et al. Rho kinase inhibitors: A novel therapeutical intervention in asthma? Eur. J. Pharmacol. 2008, 585(2-3), 398-406.

List of publications using Y 27632 dihydrochloride (Axon 1683) purchased from Axon Medchem

Cell Signaling & Oncology Stem Cell ROCK TGF-β EC 2.7.11.1

ROCK1 and ROCK2 inhibitor

Chemical name

trans-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

Parent CAS No.

[146986-50-7]

产品资料