产品名称

Locostatin - UIC 1005

产品货号

Axon 2590 CAS [90719-30-5] MF C14H15NO3MW 245.27 Purity: 100% Optical purity: Optically pure Soluble in DMSO and Ethanol Description Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor; disrupts the interaction of RKIP, not only with Raf-1 kinase, but also with GRK2; Locostatin is an inhibitor of cell sheet migration and cell growth in an epithelial cell proliferation assay, and it induced T cell anergy by blocking cytokine production after Ag recall. Other evidence suggested that Locostatin’s effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. KEYWORDS: Locostatin | supplier | RKIP/Raf inhibitor | UIC 1005 | UIC1005 | (N-crotonyl)-(4S)-isopropyl-2-oxazolidinone | (S)-(+)-4-benzyl-3-crotonyl-2-oxazolidinone | CAS [90719-30-5] | MAPK | MEK | RAF | Inhibitor | PEBP1 | Phosphatidylethanolamine Binding Protein | cell sheet migration | NF-kB | NIK | PKC | GPCR kinase 2

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Locostatin - UIC 1005

Based on 102 reference(s) in Google Scholar 10 10 102

Axon 2590

CAS [90719-30-5]

MF C14H15NO3
MW 245.27

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO and Ethanol

Locostatin

Description

Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor; disrupts the interaction of RKIP, not only with Raf-1 kinase, but also with GRK2; Locostatin is an inhibitor of cell sheet migration and cell growth in an epithelial cell proliferation assay, and it induced T cell anergy by blocking cytokine production after Ag recall. Other evidence suggested that Locostatin’s effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling.