产品名称

Dolutegravir - GSK 1349572 | Soltegravir | Tivicay

产品货号

Axon 2855 CAS [1051375-16-6] MF C20H19F2N3O5MW 419.38 Purity: 99% Soluble in DMSO Description Dolutegravir is an HIV integrase inhibitor with potent in vitro anti-HIV activity (IC50 value of 0.51 nM), an in vitro resistance profile different from those of other integrase inhibitors, and favorable preclinical safety and pharmacokinetics. KEYWORDS: Dolutegravir | supplier | HIV integrase inhibitor | GSK 1349572 | Soltegravir | Tivicay | GSK1349572 | GSK-1349572 | CAS [1051375-16-6] | DNA | HIV | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Dolutegravir - GSK 1349572 | Soltegravir | Tivicay

Based on 130 reference(s) in Google Scholar 8 10 130

Axon 2855

CAS [1051375-16-6]

MF C20H19F2N3O5
MW 419.38

Purity: 99%
Soluble in DMSO

Dolutegravir

Description

Dolutegravir is an HIV integrase inhibitor with potent in vitro anti-HIV activity (IC50 value of 0.51 nM), an in vitro resistance profile different from those of other integrase inhibitors, and favorable preclinical safety and pharmacokinetics.

KEYWORDS: Dolutegravir | supplier | HIV integrase inhibitor | GSK 1349572 | Soltegravir | Tivicay | GSK1349572 | GSK-1349572 | CAS [1051375-16-6] | DNA | HIV | Inhibitor | Enzymes

S Min et al. Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2010 Jan;54(1):254-8.

S Hare et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72.

Immunology HIV

HIV integrase inhibitor

Chemical name

(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide

Parent CAS No.

[1051375-16-6]

产品资料