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产品名称 BIBR 1532
产品货号 Axon 2301 CAS [321674-73-1] MF C21H17NO3MW 331.36 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of native and recombinant human telomerase (IC50 values of ca. 100 nM), capable of inducing senescence in human cancer cells. BIBR1532 is a mixed-type non-competitive inhibitor of the human telomerase reverse transcriptase and human telomerase RNA components with similar potency primarily by interfering with the processivity of the enzyme. BIBR 1532 defines a novel class of mixed-type non-competitive telomerase inhibitor with mechanistic similarities to non-nucleosidic inhibitors of HIV1 reverse transcriptase. References Certificates Categories Extra info E. Pascolo et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J. Biol. Chem. 2002, 277, 15566-15572.   D.K. Barma et al. Inhibition of telomerase by BIBR 1532 and related analogues. Bioorg. Med. Chem. Lett. 2003, 13, 1333-1336.   K. Damm et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. E.M.B.O.J. 2001, 20, 6958-6968. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology RT p53-Tumor Suppression DNA-damage Response EC 2.7.7.49 Telomerase Potent and selective telomerase inhibitor inducing senescence in human cancer cells. Chemical name (E)-2-(3-(Naphthalen-2-yl)but-2-enamido)benzoic acid Parent CAS No. [321674-73-1] Order Size Unit Price Stock 5 mg €70.00 In Stock
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BIBR 1532

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2301

CAS [321674-73-1]

MF C21H17NO3
MW 331.36

  • Purity: 99%
  • Soluble in DMSO

BIBR 1532

Description

Potent and selective inhibitor of native and recombinant human telomerase (IC50 values of ca. 100 nM), capable of inducing senescence in human cancer cells. BIBR1532 is a mixed-type non-competitive inhibitor of the human telomerase reverse transcriptase and human telomerase RNA components with similar potency primarily by interfering with the processivity of the enzyme. BIBR 1532 defines a novel class of mixed-type non-competitive telomerase inhibitor with mechanistic similarities to non-nucleosidic inhibitors of HIV1 reverse transcriptase.
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