产品名称

IMD-0354

产品货号

Axon 2725 CAS [978-62-1] MF C15H8ClF6NO2MW 383.67 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description The IκB kinase-β (IKKβ or IKK-2) inhibitor IMD-0354 inhibited nuclear translocation of NF-κB induced by TNF-α; this attenuated myocardial reperfusion injury and preserved cardiac function after myocardial infarction. TNF-α-induced production of interleukin-1β and monocyte chemoattractant protein-1 was reduced significantly by IMD-0354. IMD-0354 restrained proliferation of mast cells with c-kit mutations and suppressed the growth of human breast cancer cells by arresting cell cycle at the G0-G1 phase and inducing apoptosis. May effectively prevent restenosis. KEYWORD: IMD-0354 | supplier | IKK-2 inhibitor | IMD0354 | IMD 0354 | CAS [978-62-1] | IκB | IKK | Inhibitor | Enzymes | IκB kinase-β | NF-κB | TNF-α | restenosis | breast cancer

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

IMD-0354

Based on 57 reference(s) in Google Scholar 8 10 57

Axon 2725

CAS [978-62-1]

MF C15H8ClF6NO2
MW 383.67

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

IMD-0354

Description

The IκB kinase-β (IKKβ or IKK-2) inhibitor IMD-0354 inhibited nuclear translocation of NF-κB induced by TNF-α; this attenuated myocardial reperfusion injury and preserved cardiac function after myocardial infarction. TNF-α-induced production of interleukin-1β and monocyte chemoattractant protein-1 was reduced significantly by IMD-0354. IMD-0354 restrained proliferation of mast cells with c-kit mutations and suppressed the growth of human breast cancer cells by arresting cell cycle at the G0-G1 phase and inducing apoptosis. May effectively prevent restenosis.