| 产品名称 | L67 |
| 产品货号 | Axon 2549 CAS [325970-71-6] MF C16H14Br2N4O4MW 486.11 Purity: 99% Soluble in DMSO Description Cytotoxic inhibitor of DNA ligase I and III (IC50 values 10 μM each) that binds to the DBD of hLigI, hence leading to inhibition of DNA binding and ligation and specifically sensitizes cancer cells to DNA damage. Breast cancer cell lines with acquired resistance to antiestrogen therapeutics are hypersensitive to a combination of L67 and PARP inhibitor ABT 888 (Axon 1593). KEYWORDS: L67 | supplier | DNA ligase inhibitor | L-67 | CAS [325970-71-6] | DNA-RNA | DNA-ligase | Inhibitor | cytotoxic | breast | cancer | replication | double-strand break | DSB | DNA damage | NHEJ | ATP-dependent |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
L67Axon 2549 CAS [325970-71-6] MF C16H14Br2N4O4
DescriptionCytotoxic inhibitor of DNA ligase I and III (IC50 values 10 μM each) that binds to the DBD of hLigI, hence leading to inhibition of DNA binding and ligation and specifically sensitizes cancer cells to DNA damage. Breast cancer cell lines with acquired resistance to antiestrogen therapeutics are hypersensitive to a combination of L67 and PARP inhibitor ABT 888 (Axon 1593). KEYWORDS: L67 | supplier | DNA ligase inhibitor | L-67 | CAS [325970-71-6] | DNA-RNA | DNA-ligase | Inhibitor | cytotoxic | breast | cancer | replication | double-strand break | DSB | DNA damage | NHEJ | ATP-dependent
Cytotoxic inhibitor of DNA ligase I and III
Chemical name2-(3,5-dibromo-4-methylphenylamino)-N'-(2-hydroxy-5-nitrobenzylidene)acetohydrazide Parent CAS No.[325970-71-6] |
| 产品资料 |
