产品名称

Taselisib - GDC 0032 | RG 7604

产品货号

Axon 2927 CAS [1282512-48-4] MF C24H28N8O2MW 460.53 Purity: 99% Soluble in DMSO Description Taselisib is a β-sparing PI3K inhibitor with Ki values of 0.29, 0.12 and 0.97 nM for PI3Kα, PI3Kδ and PI3Kγ, respectively. Moreover, Taselisib showed improved unbound drug exposure and effectively suppressed growth of tumors in a mouse xenograft model at low drug dose levels. KEYWORDS: Taselisib | supplier | PI3K inhibitor | GDC 0032 | RG 7604 | GDC0032 | GDC-0032 | RG7604 | RG-7604 | CAS [1282512-48-4] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | Antitumor

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Taselisib - GDC 0032 | RG 7604

Based on 27 reference(s) in Google Scholar 8 10 27

Axon 2927

CAS [1282512-48-4]

MF C24H28N8O2
MW 460.53

Purity: 99%
Soluble in DMSO

Taselisib

Description

Taselisib is a β-sparing PI3K inhibitor with Ki values of 0.29, 0.12 and 0.97 nM for PI3Kα, PI3Kδ and PI3Kγ, respectively. Moreover, Taselisib showed improved unbound drug exposure and effectively suppressed growth of tumors in a mouse xenograft model at low drug dose levels.

KEYWORDS: Taselisib | supplier | PI3K inhibitor | GDC 0032 | RG 7604 | GDC0032 | GDC-0032 | RG7604 | RG-7604 | CAS [1282512-48-4] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | Antitumor

CO Ndubaku et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. J Med Chem. 2013 Jun 13;56(11):4597-610.

PI3K inhibitor (p110 β sparing)

Chemical name

2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide

Parent CAS No.

[1282512-48-4]

产品资料