| 产品名称 | ML 351 |
| 产品货号 | Axon 2312 CAS [847163-28-4] MF C15H11N3OMW 249.27 Purity: 98% Soluble in DMSO Description Potent and selective inhibitor of 12/15-lipoxygenase (IC50 value 200 nM against human 12/15-LOX) with >250-fold selectivity versus related LOX isozymes. ML351 is protective against oxidative glutamate toxicity in mouse neuronal HT22 cells and does not reduce the active-site ferric ion. ML 351 significantly reduced infarct size following permanent focal ischemia in a mouse model of ischemic stroke References Certificates Categories Extra info G. Rai et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J. Med. Chem. 2014, 57, 4035-4048. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cardiovascular Cell Signaling & Oncology CNS Diabetes & Metabolism Pain & Inflammation LOX EC 1.13.11.31 Potent and selective inhibitor of 12/15-lipoxygenase (LOX) Chemical name 5-(methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile Parent CAS No. [847163-28-4] Order Size Unit Price Stock 5 mg €125.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
ML 351Axon 2312 CAS [847163-28-4] MF C15H11N3O
Description
Potent and selective inhibitor of 12/15-lipoxygenase (IC50 value 200 nM against human 12/15-LOX) with >250-fold selectivity versus related LOX isozymes. ML351 is protective against oxidative glutamate toxicity in mouse neuronal HT22 cells and does not reduce the active-site ferric ion. ML 351 significantly reduced infarct size following permanent focal ischemia in a mouse model of ischemic stroke
Potent and selective inhibitor of 12/15-lipoxygenase (LOX)
Chemical name5-(methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile Parent CAS No.[847163-28-4] |
| 产品资料 |
