| 产品名称 | AZD 2461 |
| 产品货号 | Axon 2241 CAS [1174043-16-3] MF C22H22FN3O3MW 395.43 Purity: 99% Soluble in DMSO Description PARP inhibitor (IC50 value 5 nM) with poor P-glycoprotein substrate qualities. Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance. KEYWORDS: AZD 2461 | supplier | PARP inhibitor | AZD2461 | AZD-2461 | CAS [1174043-16-3] | DNA-RNA | PARP1 | P-gp | AZD 2281 | Olaparib | drug resistance | tumors | p53 | binding protein 1 | 53BP1 | PARPi | resistance |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
AZD 2461Axon 2241 CAS [1174043-16-3] MF C22H22FN3O3
DescriptionPARP inhibitor (IC50 value 5 nM) with poor P-glycoprotein substrate qualities. Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance. KEYWORDS: AZD 2461 | supplier | PARP inhibitor | AZD2461 | AZD-2461 | CAS [1174043-16-3] | DNA-RNA | PARP1 | P-gp | AZD 2281 | Olaparib | drug resistance | tumors | p53 | binding protein 1 | 53BP1 | PARPi | resistance
PARP inhibitor with poor P-glycoprotein substrate qualities
Chemical name4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one Parent CAS No.[1174043-16-3] |
| 产品资料 |
