| 产品名称 | PF 5274857 hydrochloride - PF 05274857 hydrochloride |
| 产品货号 | Axon 2027 CAS [1373615-35-0] MF C20H25ClN4O3S.HClMW 473.42 Purity: 99% Soluble in water and DMSO Description Potent and selective smoothened (SMO) antagonist with Ki value of 4.6 nM; a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway References Certificates Categories Extra info A Rohner et al. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Mol Cancer Ther. 2012, 11(1), 57-65. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Stem Cell Smoothened (SMO) Hedgehog F Pfizer Licensed Products Smoothened (SMO) antagonist Chemical name 1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [1373615-35-0] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
PF 5274857 hydrochloride - PF 05274857 hydrochlorideAxon 2027 CAS [1373615-35-0] MF C20H25ClN4O3S.HCl
Description
Potent and selective smoothened (SMO) antagonist with Ki value of 4.6 nM; a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway
Smoothened (SMO) antagonist
Chemical name1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride Source informationPfizer compound; Sold for research purposes under agreement from Pfizer Inc.Parent CAS No.[1373615-35-0] |
| 产品资料 |
