产品名称

iCRT14 - CRT Inhibitor iCRT14

产品货号

Axon 2135 CAS [677331-12-3] MF C21H17N3O2SMW 375.44 Purity: 98% Soluble in DMSO Description Small-molecule inhibitor of the Wnt/wingless signaling pathway (IC50 value 40 nM in a Wnt responsive STF16-luc reporter assay) that antagonizes the transcriptional function of nuclear β-catenin, and inhibits direct interactions between β-cat and TCF4. iCRT 14 exhibits specific cytotoxicity towards human colon tumor biopsy cultures as well as colon cancer cell lines that exhibit deregulated Wnt signaling. Similar mode of action as iCRT5 (Axon 2133) References Certificates Categories Extra info FC Gonsalves et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA 2011, 108, 5954-5963. BA Narayanan et al. Antagonistic Effect of Small-molecule Inhibitors of Wnt/β-catenin in Multiple Myeloma. Anticancer Res. 2012, 32(11), 4697-4707. JN Anastas & RT Moon. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 2013, 13, 11-26. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell β-Catenin Wnt-β-Catenin Wnt Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor Chemical name 5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-3-phenylthiazolidine-2,4-dione Parent CAS No. [677331-12-3] Order Size Unit Price Stock 10 mg €135.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

iCRT14 - CRT Inhibitor iCRT14

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2135

CAS [677331-12-3]

MF C21H17N3O2S
MW 375.44

Purity: 98%
Soluble in DMSO

iCRT14

Description

Small-molecule inhibitor of the Wnt/wingless signaling pathway (IC50 value 40 nM in a Wnt responsive STF16-luc reporter assay) that antagonizes the transcriptional function of nuclear β-catenin, and inhibits direct interactions between β-cat and TCF4. iCRT 14 exhibits specific cytotoxicity towards human colon tumor biopsy cultures as well as colon cancer cell lines that exhibit deregulated Wnt signaling. Similar mode of action as iCRT5 (Axon 2133)