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产品名称 WAY 316606 hydrochloride
产品货号 Axon 2325 CAS [915759-45-4 (parent)] MF C18H19F3N2O4S2.HClMW 484.94 Purity: 99% Soluble in DMSO Description Potent and water soluble inhibitor of secreted Frizzled-Related Protein I (sFRP-1; Kd value 0.08 μM and EC50 value 0.65 μM for Wnt-luciferase activity from U2-OS cells) that stimulates the Wnt/β-catenin canonical signaling pathway. WAY316606 increased total bone area in a murine calvarial organ culture assay at concentrations as low as 0.0001 μM. WAY-316606 also bound to sFRP-2, albeit over 10 times weaker (Kd value 1.0 μM) and shows moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2 > 60 min in each species). This product is not intended/sold for (self-)diagnostic and/or therapeutic use. References Certificates Categories Extra info W.J. Moore et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem. 2009 Jan 8;52(1):105-16.   W.J. Moore et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg Med Chem. 2010 Jan 1;18(1):190-201.   P.V. Bodine et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8. Certificate of Analysis Material Safety Data Sheet Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Wnt-β-Catenin Wnt Potent inhibitor of sFRP-1 that stimulates Wnt signaling Chemical name 5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide hydrochloride Parent CAS No. [915759-45-4] Order Size Unit Price Stock 2 mg €85.00 In Stock
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WAY 316606 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2325

CAS [915759-45-4 (parent)]

MF C18H19F3N2O4S2.HCl
MW 484.94

  • Purity: 99%
  • Soluble in DMSO

WAY 316606 hydrochloride

Description

Potent and water soluble inhibitor of secreted Frizzled-Related Protein I (sFRP-1; Kd value 0.08 μM and EC50 value 0.65 μM for Wnt-luciferase activity from U2-OS cells) that stimulates the Wnt/β-catenin canonical signaling pathway. WAY316606 increased total bone area in a murine calvarial organ culture assay at concentrations as low as 0.0001 μM. WAY-316606 also bound to sFRP-2, albeit over 10 times weaker (Kd value 1.0 μM) and shows moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2 > 60 min in each species).

This product is not intended/sold for (self-)diagnostic and/or therapeutic use.
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