产品名称

SB 525334

产品货号

Axon 2285 CAS [356559-20-1] MF C21H21N5MW 343.42 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of the ALK5 receptor (IC50 value 14.3 nM). SB 525334 is approximately 4-fold less potent as an inhibitor of ALK4, and inactive as an inhibitor of ALK2, ALK3, and ALK6. In cell-based assays, SB 525334 blocked TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in renal epithelial carcinoma cells. References Certificates Categories Extra info O. Fuchs. Inhibition of TGF-β signaling for the treatment of tumor metastasis and fibrotic diseases. Curr. Signal Trans. Ther. 2011, 6, 29-43. N.J. Laping et al. Tumor-Specific Efficacy of Transforming Growth Factor-βRI Inhibition in Eker Rats. Clin. Cancer Res. 2007, 13, 3087-3099. E.T. Grygielko et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J. Pharmacol. Exp. Ther. 2005, 313, 943-951. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class I; EC 2.7.11.30 TGF-βR Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor Chemical name 6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline Parent CAS No. [356559-20-1] Order Size Unit Price Stock 10 mg €105.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SB 525334

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2285

CAS [356559-20-1]

MF C21H21N5
MW 343.42

Purity: 99%
Soluble in DMSO

SB 525334

Description

Potent and selective inhibitor of the ALK5 receptor (IC50 value 14.3 nM). SB 525334 is approximately 4-fold less potent as an inhibitor of ALK4, and inactive as an inhibitor of ALK2, ALK3, and ALK6. In cell-based assays, SB 525334 blocked TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in renal epithelial carcinoma cells.