| 产品名称 | Amuvatinib - MP 470 |
| 产品货号 | Axon 2368 CAS [850879-09-3] MF C23H21N5O3SMW 447.51 Purity: 99% Soluble in DMSO Description RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met (IC50 values low µM range in vivo). Amuvatinib influences various survival and DNA repair related proteins such as pAKT, RAD51 and GSK-3β, inhibits cell proliferation, induces cell growth arrest and promotes apoptosis in prostate LNCaP cancer cells with low μM IC50 values. When combined with Erlotinib (Axon 1128), Amuvatinib abolished HER family/PI3K/Akt pathway with associated tumor growth inhibition in prostate cancer. References Certificates Categories Extra info W. Qi et al. MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer. BMC Cancer. 2009, 9, 142. D. Mahadevan et al. A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors. Oncogene. 2007, , 26, 3909-3919. C.J. Phillip et al. Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines. J. Hematol. Oncol. 2013, 6, 1-16. J.W. Welsh et al. The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells. Radiat. Oncol. 2009, 4, 69. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Cycle Regulation Cell Signaling & Oncology BCR-ABL c-MET FLT3 PDGFR PI3K-Akt-mTOR c-KIT RTK class III; EC 2.7.10.1 RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met Chemical name N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide Parent CAS No. [850879-09-3] Order Size Unit Price Stock 10 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Amuvatinib - MP 470Axon 2368 CAS [850879-09-3] MF C23H21N5O3S
DescriptionRTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met (IC50 values low µM range in vivo). Amuvatinib influences various survival and DNA repair related proteins such as pAKT, RAD51 and GSK-3β, inhibits cell proliferation, induces cell growth arrest and promotes apoptosis in prostate LNCaP cancer cells with low μM IC50 values. When combined with Erlotinib (Axon 1128), Amuvatinib abolished HER family/PI3K/Akt pathway with associated tumor growth inhibition in prostate cancer.
RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met
Chemical nameN-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide Parent CAS No.[850879-09-3] |
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