产品名称

PD 161570

产品货号

Axon 2098 CAS [192705-80-9] MF C26H35Cl2N7OMW 532.51 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Selective FGFR inhibitor; with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. PD 161570 suppressed constitutive phosphorylation of FGFR1 in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGFR1 and blocked the growth of A121(p) cells in culture. KEYWORDS: PD 161570 | supplier | FGFR inhibitor | PD161570 | CAS [192705-80-9] | FGF | FGFR | Inhibitor | Receptors

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

PD 161570

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2098

CAS [192705-80-9]

MF C26H35Cl2N7O
MW 532.51

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

PD 161570

Description

Selective FGFR inhibitor; with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. PD 161570 suppressed constitutive phosphorylation of FGFR1 in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGFR1 and blocked the growth of A121(p) cells in culture.

MC Schroeder et al. Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure-Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity. J. Med. Chem. 2001, 44(12), 1915-1926.

BL Batley et al. Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sciences 1997, 62(2), 143-150.

Angiogenesis Cell Signaling & Oncology Stem Cell RTK class V; EC 2.7.10.1 FGFR Pfizer Licensed Products

Selective FGFR1 inhibitor

Chemical name

1-tert-butyl-3-(6-(2,6-dichlorophenyl)-2-(4-(diethylamino)butylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[192705-80-9]

产品资料