产品名称

AP 24534 - Ponatinib

产品货号

Axon 1857 CAS [943319-70-8] MF C29H27F3N6OMW 532.56 Purity: 98% Soluble in DMSO Description Potent and orally active tyrosine kinase inhibitor, targeting BCR-ABL and multiple RTK References Certificates Categories Extra info T O'Hare et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009, 16(5), 401-412. WS Huang et al. Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of (...). J. Med. Chem. 2010, 53(12), 4701-4719. T Zhou et al. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem. Biol. Drug Des. 2011, 77(1), 1-11. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology BCR-ABL Oncogene Fusion Proteins EC 2.7.10.1 BCR-ABL kinase inhibitor (including T315I mutation) Chemical name 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Parent CAS No. [943319-70-8] Order Size Unit Price Stock 5 mg €90.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AP 24534 - Ponatinib

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1857

CAS [943319-70-8]

MF C29H27F3N6O
MW 532.56

Purity: 98%
Soluble in DMSO

AP 24534

Description

Potent and orally active tyrosine kinase inhibitor, targeting BCR-ABL and multiple RTK

T O'Hare et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009, 16(5), 401-412.

WS Huang et al. Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of (...). J. Med. Chem. 2010, 53(12), 4701-4719.

T Zhou et al. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem. Biol. Drug Des. 2011, 77(1), 1-11.

BCR-ABL kinase inhibitor (including T315I mutation)

Chemical name

3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Parent CAS No.

[943319-70-8]

产品资料