| 产品名称 | PD 180970 |
| 产品货号 | Axon 1137 CAS [287204-45-9] MF C21H15Cl2FN4OMW 429.27 Purity: 99% Soluble in DMSO Description PD180970 inhibits p210(Bcr-Abl) tyrosine kinase and induces apoptosis in Bcr-Abl-expressing leukemic cells References Certificates Categories Extra info P La Rosée et al. Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res. 2002, 62 (24), 7149-53. TS May. Gleevec: tailoring to fit. Drug Discovery Today (DDT), 2003, 8 (5), 188-189. M Huang et al. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene. 2002, 21(57), 8814-8816. JM Goldman, JV Melo. BCR-ABL in Chronic Myelogenous Leukemia - How Does It Work? Acta Haematol 2008, 119, 212-217. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology BCR-ABL Oncogene Fusion Proteins EC 2.7.10.1 Bcr-Abl tyrosine kinase inhibitor (p210 specific) Chemical name 6-(2,6-Dichloro-phenyl)-2-(4-fluoro-3-methyl-phenylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one Parent CAS No. [287204-45-9] Order Size Unit Price Stock 10 mg €120.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
PD 180970Axon 1137 CAS [287204-45-9] MF C21H15Cl2FN4O
Description
PD180970 inhibits p210(Bcr-Abl) tyrosine kinase and induces apoptosis in Bcr-Abl-expressing leukemic cells
Bcr-Abl tyrosine kinase inhibitor (p210 specific)
Chemical name6-(2,6-Dichloro-phenyl)-2-(4-fluoro-3-methyl-phenylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one Parent CAS No.[287204-45-9] |
| 产品资料 |
