| 产品名称 | LY 2874455 - LM 1476 |
| 产品货号 | Axon 1981 CAS [1254473-64-7] MF C21H19Cl2N5O2MW 444.31 Purity: 99% Soluble in DMSO Description Potent and selective FGFR inhibitor; LY2874455 inhibits autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 (with in vitro IC50 values of 2.8, 2.6, 6.4, and 6 nM, respectively), which is required for activation of FGF-induced downstream signaling References Certificates Categories Extra info G Zhao et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows A Potent Broad-spectrum of Anti-tumor Activity in Several Tumor Xenograft Models. Mol. Cancer Ther. 2011, 10, 2200. AN Brooks et al. Molecular Pathways: Fibroblast Growth Factor Signaling: A New Therapeutic Opportunity in Cancer. Clin. Cancer Res. 2012, 18, 1855. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology RTK class V; EC 2.7.10.1 FGFR Potent and selective FGFR inhibitor Chemical name (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol Parent CAS No. [1254473-64-7] Order Size Unit Price Stock 2 mg €110.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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LY 2874455 - LM 1476Axon 1981 CAS [1254473-64-7] MF C21H19Cl2N5O2
Description
Potent and selective FGFR inhibitor; LY2874455 inhibits autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 (with in vitro IC50 values of 2.8, 2.6, 6.4, and 6 nM, respectively), which is required for activation of FGF-induced downstream signaling
Potent and selective FGFR inhibitor
Chemical name(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol Parent CAS No.[1254473-64-7] |
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