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产品名称 SSR 128129E
产品货号 Axon 2234 CAS [848318-25-2] MF C18H15N2NaO4MW 346.31 Purity: 99% Soluble in water and DMSO Description Extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling with oral bioavailability. SSR 128129E inhibits responses mediated by FGFR1-4 (IC50 values 15-28 nM for FGF2 induced FGFR stimulation), but not by other related RTKs.SSR 128129E does not inhibit all FGFR signaling pathways indiscriminatively but selectively blocks particular signaling pathways, dependent on the cellular context. Capable of inhibiting angiogenesis, inflammation, and bone resorption in arthritis, and delays tumor growth and metastasis. References Certificates Categories Extra info C. Herbert et al. Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell. 2013, 23, 489-501.    F. Bono et al. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell. 2013, 23, 477-488.  Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology Pain & Inflammation RTK class V; EC 2.7.10.1 FGFR Allosteric inhibitor of FGF receptor signaling Chemical name sodium 2-amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoate Parent CAS No. [848463-13-8] Order Size Unit Price Stock 10 mg €99.00 In Stock
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SSR 128129E

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2234

CAS [848318-25-2]

MF C18H15N2NaO4
MW 346.31

  • Purity: 99%
  • Soluble in water and DMSO

SSR 128129E

Description

Extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling with oral bioavailability. SSR 128129E inhibits responses mediated by FGFR1-4 (IC50 values 15-28 nM for FGF2 induced FGFR stimulation), but not by other related RTKs.SSR 128129E does not inhibit all FGFR signaling pathways indiscriminatively but selectively blocks particular signaling pathways, dependent on the cellular context. Capable of inhibiting angiogenesis, inflammation, and bone resorption in arthritis, and delays tumor growth and metastasis.
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