产品名称

RIPA-56

产品货号

Axon 2677 CAS [1956370-21-0] MF C13H19NO2MW 221.30 Purity: 99% Soluble in DMSO Description Highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1; IC50 value 13 nM) for the treatment of systemic inflammatory response syndrome (SIRS). RIPA-56 efficiently reduced TNFα-induced mortality and multiorgan damage. KEYWORDS: RIPA-56 | supplier | RIP1 inhibitor | RIPA56 | RIPA 56 | CAS [1956370-21-0] | Axon Medchem | Axon 2677 | RIP kinase | SIRS | necrotic cell death pathway | inflammation

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

RIPA-56

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2677

CAS [1956370-21-0]

MF C13H19NO2
MW 221.30

Purity: 99%
Soluble in DMSO

RIPA-56

Description

Highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1; IC50 value 13 nM) for the treatment of systemic inflammatory response syndrome (SIRS). RIPA-56 efficiently reduced TNFα-induced mortality and multiorgan damage.

Y Ren et al. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem. 2017 Feb 9;60(3):972-986.

RIP1 inhibitor for the treatment of systemic inflammatory response syndrome

Chemical name

N-benzyl-N-hydroxy-2,2-dimethylbutanamide

Parent CAS No.

[1956370-21-0]

产品资料