| 产品名称 | Santacruzamate A - CAY 10683 |
| 产品货号 | Axon 2495 CAS [1477949-42-0] MF C15H22N2O3MW 278.35 Purity: 99% Soluble in DMSO Description Picomolar level Class I HDAC2 inhibitor (IC50 value 0.11 nM) with relatively little inhibition of HDAC4 or HDAC6 (IC50 values >1000 nM and 433 nM, respectively). Cytotoxin with several structural features in common with Vorinostat, a clinically approved HDAC inhibitor used to treat refractory cutaneous T-cell lymphoma. Note: Potency of synthetic Santacruzamate A is questioned due to lack of cytotoxicity tested in two cancer cell lines (Q. Liu et al. 2015) References Certificates Categories Extra info C.M. Pavlik et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. Q. Liu et al. Synthesis and biological evaluation of santacruzamate A and analogs as potential anticancer agents. RSC Adv. 2015,5, 1109-1112. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC Picomolar level HDAC2 inhibitor with little inhibition of HDAC4 and HDAC6 Chemical name ethyl 4-oxo-4-(phenethylamino)butylcarbamate Parent CAS No. [1477949-42-0] Order Size Unit Price Stock 10 mg €85.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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Santacruzamate A - CAY 10683Axon 2495 CAS [1477949-42-0] MF C15H22N2O3
DescriptionPicomolar level Class I HDAC2 inhibitor (IC50 value 0.11 nM) with relatively little inhibition of HDAC4 or HDAC6 (IC50 values >1000 nM and 433 nM, respectively). Cytotoxin with several structural features in common with Vorinostat, a clinically approved HDAC inhibitor used to treat refractory cutaneous T-cell lymphoma. Note: Potency of synthetic Santacruzamate A is questioned due to lack of cytotoxicity tested in two cancer cell lines (Q. Liu et al. 2015)
Picomolar level HDAC2 inhibitor with little inhibition of HDAC4 and HDAC6
Chemical nameethyl 4-oxo-4-(phenethylamino)butylcarbamate Parent CAS No.[1477949-42-0] |
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