| 产品名称 | MS 275 - Entinostat | SNDX 275 |
| 产品货号 | Axon 1803 CAS [209783-80-2] MF C21H20N4O3MW 376.41 Purity: 99% Soluble in DMSO Description Potent and long-lasting histone deacetylase (HDAC) inhibitor undergoing clinical trials for treatment of various cancers; Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively References Certificates Categories Extra info A Saito et al. A synthetic inhibitor of histone deacetylase, MS-275, with marked in vivo antitumor activity against human tumors. Proc. Natl. Acad. Sci. USA 1999, 96, 4592-4597. M. V. Simonini et al. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc. Natl. Acad. Sci. USA 2006, 103(5), 1587-1592. IY Eyüpoglu et al. Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275. Mol. Cancer Ther. 2006, 5, 1248-1255. HS Lin et al. Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br. J. Pharmacol. 2007, 150, 862-872. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC Inhibitor of HDAC (1 and 3 Selective) Chemical name pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate Parent CAS No. [209783-80-2] Order Size Unit Price Stock 10 mg €80.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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MS 275 - Entinostat | SNDX 275Axon 1803 CAS [209783-80-2] MF C21H20N4O3
Description
Potent and long-lasting histone deacetylase (HDAC) inhibitor undergoing clinical trials for treatment of various cancers; Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively
Inhibitor of HDAC (1 and 3 Selective)
Chemical namepyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate Parent CAS No.[209783-80-2] |
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