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产品名称 Dorsomorphin
产品货号 Axon 1708 CAS [866405-64-3] MF C24H25N5OMW 399.49 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Selective inhibitor of BMP signaling; functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation; Also a AMPK inhibitor (Ki value 109 nM) * Note: The water-soluble form, Dorsomorphin dihydrochloride (Axon 2150) is also available. References Certificates Categories Extra info PB Yu et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2007, 4(1), 33-41.   J Hao et al. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 2008, 3(8), e2904.   JH Boergermann et al. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Intl. J. Biochem. Cell Biol. 2010, 42(11), 1802-1807. Certificate of Analysis Material Safety Data Sheet Apoptosis Stem Cell TGF-β RSTK class I; EC 2.7.11.30 Stem Cell Differentiator BMP-ALK Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 Chemical name 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Parent CAS No. [866405-64-3] Order Size Unit Price Stock 2 mg €65.00 In Stock
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Dorsomorphin

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1708

CAS [866405-64-3]

MF C24H25N5O
MW 399.49

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

Dorsomorphin

Description

Selective inhibitor of BMP signaling; functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation; Also a AMPK inhibitor (Ki value 109 nM)

* Note: The water-soluble form, Dorsomorphin dihydrochloride (Axon 2150) is also available.
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