| 产品名称 | NVP-AUY922 - VER 52296 | Luminespib |
| 产品货号 | Axon 1542 CAS [747412-49-3] MF C26H31N3O5MW 465.54 Purity: 98% Soluble in DMSO Description Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM References Certificates Categories Extra info MR Jensen et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 2008, 10, R33. SA Eccles et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68, 2850. PA Brough et al. 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. J. Med. Chem., 2008, 51 (2), pp 196–218. T Taldone et al. Targeting Hsp90: small-molecule inhibitors and their clinical development. Cur. Opin. Pharmacol. 2008, 8(4), 370-374. Certificate of Analysis Material Safety Data Sheet Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Hsp90 EC 3.6 Hsp90 inhibitor Chemical name 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide Parent CAS No. [747412-49-3] Order Size Unit Price Stock 5 mg €75.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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NVP-AUY922 - VER 52296 | LuminespibAxon 1542 CAS [747412-49-3] MF C26H31N3O5
Description
Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM
Hsp90 inhibitor
Chemical name5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide Parent CAS No.[747412-49-3] |
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