产品名称

A 841720

产品货号

Axon 2155 CAS [869802-58-4] MF C17H21N5OSMW 343.45 Purity: 99% Soluble in DMSO Description Potent and selective non-competitive mGlu1 receptor antagonist (IC50: 10 nM); showing 34-fold selectivity over mGluR5 and no significant activity at other mGluR receptors, neurotransmitter receptors, ion channels, and transporters. A 841720 demonstrated full efficacy in various in vivo animal pain models. KEYWORDS: A 841720 | supplier | mGluR1 antagonist | A841720 | A-841720 | CAS [869802-58-4] | Metabotropic | Glutamate | mGluR1 | mGlu1 | Antagonist | Receptors

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

A 841720

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2155

CAS [869802-58-4]

MF C17H21N5OS
MW 343.45

Purity: 99%
Soluble in DMSO

A 841720

Description

Potent and selective non-competitive mGlu1 receptor antagonist (IC50: 10 nM); showing 34-fold selectivity over mGluR5 and no significant activity at other mGluR receptors, neurotransmitter receptors, ion channels, and transporters. A 841720 demonstrated full efficacy in various in vivo animal pain models.

GZ Zheng et al. Structure-Activity Relationship of Triazafluorenone Derivatives as Potent and Selective mGluR1 Antagonists. J. Med. Chem. 2005, 48, 7374-7388.

O El-Kouhen et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br. J. Pharmacol. 2006, 149, 761-774.

Non-competitive mGluR1 antagonist

Chemical name

9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Parent CAS No.

[869802-58-4]

产品资料