产品名称

TFB-TBOA

产品货号

Axon 2640 CAS [480439-73-4] MF C19H17F3N2O6MW 426.34 Purity: 100% Optical purity: >97% d.e. Soluble in 0.1N NaOH(aq) and DMSO Description Very potent blocker for the human excitatory amino acid transporters (IC50 values 22 nM, 17 nM, and 300 nM, for EAAT1, EAAT2, and EAAT3, respectively). TFB-BOA is more potent at inhibiting EAAT1 and EAAT2 compared with L-TBOA (Axon 2427), and induced spontaneous epileptiform discharges and convulsive behaviors in mice. An important tool for elucidation of the physiological roles of EAATs and their contribution to the etiology of neuronal disorders. KEYWORDS: TFB-TBOA | supplier | EAAT blocker | L-TFB-TBOA | CAS [480439-73-4] | Glutamate | EAAT1 | EAAT2 | Blocker | excitatory amino acid transporter | convulsion | neuronal | CNS

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TFB-TBOA

Based on 56 publications in PubMed 9 10 56

Axon 2640

CAS [480439-73-4]

MF C19H17F3N2O6
MW 426.34

Purity: 100%
Optical purity: >97% d.e.
Soluble in 0.1N NaOH(aq) and DMSO

TFB-TBOA

Description

Very potent blocker for the human excitatory amino acid transporters (IC50 values 22 nM, 17 nM, and 300 nM, for EAAT1, EAAT2, and EAAT3, respectively). TFB-BOA is more potent at inhibiting EAAT1 and EAAT2 compared with L-TBOA (Axon 2427), and induced spontaneous epileptiform discharges and convulsive behaviors in mice. An important tool for elucidation of the physiological roles of EAATs and their contribution to the etiology of neuronal disorders.

H Fu et al. Rapid chemoenzymatic route to glutamate transporter inhibitor l-TFB-TBOA and related amino acids. Org Biomol Chem. 2017 Feb 28.

K Shimamoto et al. Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Mol Pharmacol. 2004 Apr;65(4):1008-15.

S Tsukada et al. Effects of a novel glutamate transporter blocker, (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA), on activities of hippocampal neurons. Neuropharmacology. 2005 Mar;48(4):479-91.

CNS EAAT

Very potent blocker of human excitatory amino acid transporters (EAAT1-2)

Chemical name

(2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido)benzyloxy)succinic acid

Parent CAS No.

[480439-73-4]

产品资料