产品名称

S 18986

产品货号

Axon 1788 CAS [175340-20-2] MF C10H12N2O2SMW 224.28 Purity: 99% Optical purity: >99% ee Soluble in DMSO Description Positive allosteric modulator of AMPA receptor with cognitive-enhancing effects; neuroprotective; long-acting and with good oral availability References Certificates Categories Extra info B Lockhart et al. (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release (...). Eur. J. Pharmacol. 2000, 401(2), 145–153. C Lebrun et al. Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. Eur. J. Pharmacol. 2000, 401(2), 205–212. SM Gupta et al. GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death Differ. 2009, 16(4), 624–637. KD Destot-Wong et al. The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology 2009, 57(3), 277–286. Certificate of Analysis Material Safety Data Sheet CNS Pain & Inflammation AMPA Unclassified Positive allosteric modulator of AMPA receptor Chemical name (+)-(S)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide Parent CAS No. [175340-20-2] Order Size Unit Price Stock 5 mg €105.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

S 18986

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1788

CAS [175340-20-2]

MF C10H12N2O2S
MW 224.28

Purity: 99%
Optical purity: >99% ee
Soluble in DMSO

S 18986

Description

Positive allosteric modulator of AMPA receptor with cognitive-enhancing effects; neuroprotective; long-acting and with good oral availability

B Lockhart et al. (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release (...). Eur. J. Pharmacol. 2000, 401(2), 145–153.

C Lebrun et al. Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. Eur. J. Pharmacol. 2000, 401(2), 205–212.

SM Gupta et al. GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death Differ. 2009, 16(4), 624–637.

KD Destot-Wong et al. The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology 2009, 57(3), 277–286.

Positive allosteric modulator of AMPA receptor

Chemical name

(+)-(S)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide

Parent CAS No.

[175340-20-2]

产品资料