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产品名称 WAY 262611 dihydrochloride
产品货号 Axon 2188 CAS [N.A.] MF C20H22N4.2HClMW 391.34 Purity: 99% Soluble in water and DMSO Description Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously. References Certificates Categories Extra info J.C. Pelletier et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J. Med. Chem. 2009, 52, 6962-6965.    J.J. Pinzone et al. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood 2009, 113, 517-525.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell Wnt-β-Catenin Wnt Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist Chemical name (1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine dihydrochloride Parent CAS No. [1123231-07-1] Order Size Unit Price Stock 10 mg €125.00 In Stock
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WAY 262611 dihydrochloride

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2188

CAS [N.A.]

MF C20H22N4.2HCl
MW 391.34

  • Purity: 99%
  • Soluble in water and DMSO

WAY 262611 dihydrochloride

Description

Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously.
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